Doccol micro catheters were specially designed for improving the performance, quality and productivity in rodent blood sampling, drug delivery, small flow rate liquid transferring, and physiological monitoring, in which invasive vascular access is necessary. Doccol provides sufficient choices of micro catheters for vascular cannulation in all common locations, such as the tail, femoral, carotid, and brachial veins and arteries, and also the jugular veins. The following features make Doccol microcatheters superior to its competitors:
- Doccol knows the frustration and pain in making and using “home-made” microcatheters, our microcatheters are permanently connected to an industrial standard Luer lock or stopcock, therefore, eliminated the transitional tubing and needle connection. Doccol microcatheters offer the convenience of direct use with in dustrial standard syringes with Luer fitting.
- Dramatically reduced inner volume allows minimal disturbance of local blood flow dynamics. For the microcatheters made of PI materials, the dead volume for catheters with FL connectors is 20-30 micro liter, for those with SC1 or SC4 connectors is 100-120 micro liter. The dead volume mainly comes from the connectors, where the space lies between the tubing inner end and the syringe tip.
- Although the microcatheters are extremely fine, they offer excellent pushability; tubing OD covering a range from 0.081 mm to 0.838 mm with sufficient choices; these features make them suitable for the access of deep microvascularure.
- Microcatheter tubings are available in several materials, such as polyimide, teflon, polyethylene, vinyl, and polyurethane.
- These microcatheters are durable and can be repeatedly used.
References:
Cherkashova, E.A., Burunova, V.V., Bukharova, T.B. et al. Comparative Analysis of the Effects of Intravenous Administration of Placental Mesenchymal Stromal Cells and Neural Progenitor Cells Derived from Induced Pluripotent Cells on the Course of Acute Ischemic Stroke in Rats. Bull Exp Biol Med 166, 558–566 (2019) doi:10.1007/s10517-019-04392-5
Namestnikova, D & Gubskiy, Il'ya & Gabashvili, A & Sukhinich, Kirill & Melnikov, Pavel & Vishnevskiy, D & Soloveva, A & Vitushev, E & Chekhonin, V & Gubsky, Leonid & Yarygin, Konstantin. (2017). MRI evaluation of frequent complications after intra-arterial transplantation of mesenchymal stem cells in rats. Journal of Physics: Conference Series. 886. 012012. 10.1088/1742-6596/886/1/012012.
Namestnikova D, Gubskiy I, Kholodenko I, Melnikov P, Sukhinich K, et al. (2017) Methodological aspects of MRI of transplanted superparamagnetic iron oxide-labeled mesenchymal stem cells in live rat brain. PLOS ONE 12(10): e0186717. https://doi.org/10.1371/journal.pone.0186717
Arnberg F, Lundberg J, Kenne E, et al. Superselective intra-arterial umbilical cord blood administration to BM in experimental animals. Bone Marrow Transplantation. 2014;49(12):1486-1491. doi:10.1038/bmt.2014.190.
To select a microcatheter, you will need to know the size of vessel that you are going to catheterize. The principal is that the outer diameter of a microcatheter should be smaller than the vessel inner diameter. You may use the following chart as a guidance in determing the tubing O.D. of your microcatheter according to the animal body weight. Tubing length can be customized.
| Maximum microcatheter O.D. (mm) for artery cannulation |
| Body Weight (g) |
Femoral |
Tail
(upper 2/3) |
Carotid
(lower 2/3) |
Brachial |
| <15 |
0.136 |
0.136 |
0.327 |
0.127 |
| 15-20 |
0.159 |
0.159 |
0.382 |
0.127 |
| 20-25 |
0.205 |
0.205 |
0.491 |
0.164 |
| 25-30 |
0.250 |
0.250 |
0.600 |
0.200 |
| 30-35 |
0.275 |
0.295 |
0.660 |
0.220 |
| <200 |
0.328 |
0.328 |
0.590 |
0.262 |
| <200-250 |
0.369 |
0.369 |
0.664 |
0.295 |
| 250-280 |
0.434 |
0.434 |
0.782 |
0.348 |
| 280-330 |
0.500 |
0.500 |
0.900 |
0.400 |
| 330-400 |
0.598 |
0.598 |
1.077 |
0.479 |
| >400 |
0.656 |
0.656 |
1.180 |
0.525 |
Doccol provides microcatheters for the following diameters:
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