Doccol Corporation DOCCOL CORPORATION Login/Register    
Carterror    
Checkout    
Serving Stroke Research Since 2004
  Top » Catalog » RODENT STROKE MODEL GUIDELINES
Products and Services
Products-> (604)
View All Products
Featured Products more
Medium A MCAO suture 60L56C
Medium A MCAO suture 60L56C
Please log in to see prices
Manufacturers
Latest News in Stroke Research
New articles referring Doccol since 2024
New PubMed records in last 7 days
Innovation
Doccol® MCAO Sutures
Doccol® Microcatheters
Doccol® Temperature Controllers
RODENT STROKE MODEL GUIDELINES
J Exp Stroke Transl Med. 2009 Jan 1;2(2):2-27.

RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION).

Liu S1, Zhen G, Meloni BP, Campbell K, Winn HR.

Author information

1Department of Neurology, Stroke Center, Mount Sinai School of Medicine of NYU, New York, NY, USA.

Abstract

Translational stroke research is a challenging task that needs long term team work of the stroke research community. Highly reproducible stroke models with excellent outcome consistence are essential for obtaining useful data from preclinical stroke trials as well as for improving inter-lab comparability. However, our review of literature shows that the infarct variation coefficient of commonly performed stroke models ranges from 5% to 200%. An overall improvement of the commonly used stroke models will further improve the quality for experimental stroke research as well as inter-lab comparability. Many factors play a significant role in causing outcome variation; however, they have not yet been adequately addressed in the Stroke Therapy Academic Industry Roundtable (STAIR) recommendations and the Good Laboratory Practice (GLP). These critical factors include selection of anesthetics, maintenance of animal physiological environment, stroke outcome observation, and model specific factors that affect success rate and variation. The authors have reviewed these major factors that have been reported to influence stroke model outcome, herewith, provide the first edition of stroke model guidelines so to initiate active discussion on this topic. We hope to reach a general agreement among stroke researchers in the near future with its successive updated versions.

Continue
Cart more
0 items
Bestsellers
01.Medium MCAO suture 40L56C
02.Fine MCAO suture 40L56C
03.Medium A MCAO suture 60L56C
04.Fine MCAO suture 60L56C
05.Medium B MCAO suture 40L56C
06.Fine MCAO suture 70L56
Currencies
Frequently Requested Information
About Doccol
Doccol made a difference
MCAO Surgery
FAQs
How to Order/Quote
Shipping and Payment
Select Monofilaments
Select Microcatheters
Distributors
Downloadable catalog
Contact Us
We accept AMX,VISA and MasterCard
Your IP Address is: 34.236.152.203

Copyright © 2024 Doccol Corporation
30 Eisenhower Drive, Sharon, MA 02067-2427, USA
Toll-free Tel: (888) 481-0842; Fax: (888) 893-5285
Discount Policy
Return Policy
Privacy Notice
Condition of Use