Doccol provides MCAO (middle cerebral artery occlusion) sutures for inducing ischemic stroke models in rats and mice since 2004, Doccol products are referred by over a thousand scholarly articles. MCAO sutures are silicone-rubber coated nylon monofilaments, in which the silicone-rubber coating is engineered for ensuring a complete occlusion of the middle cerebral artery (MCA) origin while avoiding subarachnoid hemorrhage (SAH). Using Doccol MCAO sutures for inducing stroke models has been widely accepted as a necessary technical step, and it is also a new standard for ensuring the highest quality of stroke modeling. Using Doccol MCAO sutures for inducing stroke models has been reported to be able to drastically decrease the within-group variation of stroke models, reducing the standard deviation (SD) to 5% of the mean value for infarction volume. For more information please read Doccol Made a Difference in Stroke Modeling.
MCAO sutures are available in nylon monofilament material USP size 3-0, 4-0, 5-0, 6-0, 7-0, and 8-0, which are categorized first by coating diameter, then further by coating length. We provide a match chart below to help you select coating diameters:
|
Animal Body
Weight (g)
|
Suggested
tip Diameters (mm)
|
Bare filament
USP “0”
|
|
12-15
|
0.15, 0.17
|
8-0, 7-0
|
|
15-20
|
0.17, 0.19
|
8-0, 7-0
|
|
21-25
|
0.21, 0.22
|
8-0, 7-0, 6-0
|
|
26-30
|
0.22, 0.23
|
8-0, 7-0, 6-0
|
|
31-35
|
0.23, 0.24
|
8-0, 7-0, 6-0
|
|
36-200
|
0.24 - 0.33
|
5-0, 6-0
|
|
201-250
|
0.33, 0.35
|
5-0, 4-0
|
|
251-280
|
0.35, 0.37
|
5-0, 4-0
|
|
281-330
|
0.37, 0.39
|
5-0, 4-0
|
|
331-400
|
0.41
|
4-0, 3-0
|
|
401-500
|
0.43, 0.45
|
4-0, 3-0
|
|
501-600
|
0.47, 0.49
|
4-0, 3-0
|
|
601-700
|
0.51, 0.54
|
3-0
|
|
701-800
|
0.54
|
3-0
|
|
801-900
|
0.54, 0.58
|
3-0
|
|
901-1000
|
0.58
|
3-0
|
Doccol provides MCAO sutures for the following tip (coated part) diameters: |
