This adaptor stands out for its exceptional adjustability, offering a vertical range from +10 mm to -20 mm with a fine resolution of 100 μm, accommodating various sizes and shapes of mouse heads. Additionally, it provides the capability to rotate the head horizontally within a 35° range, enabling researchers to achieve the precise angle needed for their specific experimental requirements. The careful design excludes the need for ear bars, instead securing the mouse by the palate and incisors, which is especially beneficial for procedures where traditional ear bar positioning might interfere with experimental access or where ear bars are contraindicated.