Therapeutic Potential of NLRP3 Inhibitor MCC950 in Aging Mice Stroke Outcomes

PK Kamat, MB Khan, S Siddiqui, AD Dua… - Translational Stroke …, 2026 - Springer
… Our study suggests that MCC950 is a promising therapy for acute stroke. … (doccol,
silicon-coated) was inserted (Cat# 602112PK10Re, 602212PK10Re, 602312PK10Re). A doccol …

[HTML][HTML] Reassessment of Neuroprotective Efficacy of TUDCA in Ischemic Stroke: A Multi-Model In Vivo and In Vitro Study

SM Mousavi, SN Ozmen, MA Adedokun… - International Journal of …, 2026 - mdpi.com
… metabolites as modulators of stroke outcome has positioned … either one hour before or
after stroke induction. Infarct size, … to fully evaluate its therapeutic potential in ischemic stroke. …

[HTML][HTML] Histone neutralization protects the ischemic brain against the consequences of stroke-associated pneumonia

D Yin, A Li, A Mohamud Yusuf, O Shevchuk… - Acta …, 2026 - Springer
… stroke via mechanisms that still remain to be determined. In ischemic stroke patients, we show
that stroke-… pneumoniae pneumonia induced at 3 days after stroke impaired neurological …

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

D Lapin, D Aylar, A Sharma, P Wang - Advanced Science, 2026 - Wiley Online Library
… and promoting resolution in ischemic stroke. Extracellular cold‐… stroke has not yet been
studied. Using a transient middle cerebral artery occlusion (tMCAO) model of ischemic stroke, …

Endothelial Malat1 promotes post-stroke angiogenesis and neurovascular recovery via the Tek axis

T Xiong, M Zhang, P Sun, Y Zhang, A Ni, S Zhang… - Brain, 2026 - academic.oup.com
… Ischemic stroke remains a leading cause of mortality and … post-stroke vascular remodeling
remain poorly understood. … sensorimotor and cognitive function following ischemic stroke. …

Multilaboratory, Blinded, Randomized Trial of Five Cerebroprotectants in Ischemic Stroke

C Ayata, AK Chauhan, DC Hess, B Hu… - Circulation …, 2026 - ahajournals.org
… The standard Doccol silicone-tipped nylon filament MCAo procedure was used in this trial,
as described previously. The MCAo procedure followed the method of Longa. Rats were …

Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca2+ activity

Q Ye, C Madamba, J Woo, TJ Choy, KF Wheeler… - Nature Cancer, 2026 - nature.com
… stroke are at increased risk of developing brain tumors, yet the mechanisms linking brain injury
to glioma progression remain unclear. Here we show that stroke … findings establish stroke-…

improves outcomes after stroke

SA Rupasinghe, SR Zhang… - … mechanism of stroke, 2026 - books.google.com
… stroke pathology (14). The marked ability of the spleen to contract in both preclinical models
and in stroke … autopsy non-stroke subjects and four anonymized acute ischemic stroke (AIS) …

[HTML][HTML] Salvaging the No-Reflow Zone: Intra-arterial Cranial Bone-Derived MSCs Restore Neurovascular Integrity After Stroke

T Hara, M Takeda, M Kuwabara, Y Maeda… - Translational Stroke …, 2026 - Springer
Successful macrovascular recanalization does not always translate into functional recovery,
in part because early post-reperfusion injury can drive infarct expansion. Here, we …

S-Nitrosylation of Endothelial FK506-Binding Protein 5 Impairs Angiogenesis via PHLPP-AKT Axis in Ischemic Stroke

XY Zhang, H Xu, W Guo, HL Wang, ZH Sun, YY Liu… - Stroke, 2026 - ahajournals.org
BACKGROUND: Angiogenesis contributes to vascular repair and functional recovery after
ischemic stroke, yet how nitric oxide–mediated S-nitrosylation shapes this response remains …